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Home > Health > Article

Tamiflu, Relenza: H1N1 Swine Flu

News items from Nature Journals as governments build supply of millions of doses of Tamiflu.

At least some strains of H1N1 influenza virus are resistant to the antiflu drug Tamiflu.

These strains might respond better to a second flu drug, Relenza. Furthermore, the available stocks of Tamiflu fall far short of what would be needed in a pandemic.

According to Nature Biotechnology of 31 May 2009, "...this mutation in seasonal H1N1 strains and highlights the possibility of the emergence of Tamiflu-resistant viruses." Nature Biotechnology 27, 510-513 (31 May 2009) doi:10.1038/nbt0609-510

"Tests have shown that the new H1N1 virus is susceptible to the neuraminidase inhibitors oseltamivir (Tamiflu; Roche) and zanamivir (Relenza; GlaxoSmithKline (GSK))," says the Nature Reviews Drug Discovery issue of 31 May 2009.

"Fortunately, the new H1N1 strain responds to neuraminidase inhibitors such as olsetamivir (Tamiflu, made by Roche) and zanamavir (Relenza, made by GlaxoSmithKline). Unfortunately, resistance ..." Nature Medicine 15, 585-585 (31 May 2009) doi:10.1038/nm0609-585 Editorial

"Swine flu is currently sensitive to the antiviral drug oseltamivir (Tamiflu), for example, but seasonal H1N1 is resistant. Were the new virus to acquire ... is resistant. Were the new virus to acquire resistance, that would render redundant the Tamiflu stockpiled by many nations as part of their pandemic plans." Nature 459, 490-491 (27 May 2009) doi:10.1038/459490a

"What is the risk that it will reassort with seasonal flu and develop Tamiflu resistance? It is almost a given that at some point this will reassort with ..." Nature News (13 May 2009) doi:10.1038/news.2009.478 News

Tamiflu, Relenza: Will They Protect Your Family from H5N1 Bird Flu?

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The Medical Basis for Routine Circumcision
A quest for official medical authorities of the western world that advocate child circumcision. The historical basis of the procedure.

Child Circumcision
Why was it once popular in the US? Why is it in such rapid decline today?

Protect Your Son
How a father discovered, too late, that circumcision is not a good thing.

Jews and Circumcision

The Role of Circumcision in the Islamic World
by Sami Aldeeb

Self-Test for Sexual Sensitivity
How much of your sexual sensitivity has been cut away?

Do Not Promote Circumcision for Cancer Prevention
says the American Cancer Society

Reduction Surgery
Quotes from the medical profession.

Sexual Mutilation
Quotes from internet resources.

Boy's Death Highlights New Dangers of Neonatal Circumcision
Infants experiencing circumcision are more subject to Hypovolemic Shock and Methicillin Resistant Staphyloccus Aureus (MRSA).

Horror Stories
Many live with problems resulting from involuntary circumcision.

The Circumcision Decision
Answers to your questions about infant circumcision.

Care of Intact Boys
Answers to your questions about your young son's personal care.

Listing of Publications and Organizations
Support for parents who want to protect their family from involuntary genital alteration.

Glossary of Related Terms

Non-surgical foreskin restoration.

External links:
Circumcision Decision Maker
Avoid a circumcision mistake! Learn more about this permanent decision.

Anatomy and Mechanics of Intercourse
The physical function of the foreskin.
by Geoffrey T. Falk